Research talk: Phage-microbe interactions by Ivan Liachko
Building the World’s Largest Virome-Microbe Interaction Atlas Using Proximity Ligation Sequencing Technology
Metagenomic proximity ligation sequencing is a culture-independent technique for directly associating phages, plasmids, and antimicrobial resistance (AMR) genes with their microbial hosts by capturing physical, in vivo interactions within native communities. Unlike traditional culture-based methods, this approach identifies phage-host pairs without propagating bacteria, enabling simultaneous viral genome binning (vMAGs) and assignment to microbial hosts directly from metagenomic data. Large-scale application across agricultural, environmental, and healthcare contexts has resulted in an extensive repository linking phage, plasmid, and resistance elements to their hosts, significantly advancing efforts to understand microbial modulation and combat antimicrobial resistance.
Ivan Liachko is the CSO of Phase Genomics, who basically are a company that do many things with Hi-C (see link below). One of which is using it to really focus in on phage-microbe interactions. He’s an entertaining speaker, and if you are interested in phages, well their methods are pretty cool.
His talk is at the Kommunehospital, room 22.0.19. So that’s building 22 – entrance from Bartholinsgade. The title and abstract are below. Feel free to pass this on to anyone you know who might be interested.