Seminar by Olga Dudchenko

Olga Dudchenko from Baylor College of Medicine will be visiting Center for Evolutionary Hologenomics to do a talk on 28th of August, at 11.00. The talk is entitled "Hi-C Genomes Across and Beyond the Tree of Life".

Olga and her collaborator Erez Aiden have really been pushing the limits of what you can do with Hi-C methods, and has kindly offered to give a talk.

Title: "Hi-C Genomes Across and Beyond the Tree of Life"

Abstract:

Historically, assembling end-to-end genomes has been a difficult challenge. On the one hand, consortium-level efforts spanning multiple technologies can be expensive and require biological material of exceptional quality, whereas affordable short read-based methods compatible with lower-quality samples produced highly fragmented, difficult to interpret sequences. Over the past few years we have developed several tools that apply Hi-C, a method originally developed to figure out how genomes fold in 3D, to the problem of genome assembly. These methods enable the generation of phased end-to-end genome assemblies from a wide range of samples, supporting large-scale comparative projects both across and beyond the tree of life (Dudchenko et al., Science2017; Hoencamp et al., Science2021; Moreno et al., Nature2023; Sandoval-Velasco et al., Cell2024).