The Australian dingo is an early offshoot of modern breed dogs
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The Australian dingo is an early offshoot of modern breed dogs. / Field, Matt A.; Yadav, Sonu; Dudchenko, Olga; Esvaran, Meera; Rosen, Benjamin D.; Skvortsova, Ksenia; Edwards, Richard J.; Keilwagen, Jens; Cochran, Blake J.; Manandhar, Bikash; Bustamante, Sonia; Rasmussen, Jacob Agerbo; Melvin, Richard G.; Chernoff, Barry; Omer, Arina; Colaric, Zane; Chan, Eva K. F.; Minoche, Andre E.; Smith, Timothy P. L.; Gilbert, M. Thomas P.; Bogdanovic, Ozren; Zammit, Robert A.; Thomas, Torsten; Aiden, Erez L.; Ballard, J. William O.
In: Science Advances, Vol. 8, No. 16, eabm5944, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The Australian dingo is an early offshoot of modern breed dogs
AU - Field, Matt A.
AU - Yadav, Sonu
AU - Dudchenko, Olga
AU - Esvaran, Meera
AU - Rosen, Benjamin D.
AU - Skvortsova, Ksenia
AU - Edwards, Richard J.
AU - Keilwagen, Jens
AU - Cochran, Blake J.
AU - Manandhar, Bikash
AU - Bustamante, Sonia
AU - Rasmussen, Jacob Agerbo
AU - Melvin, Richard G.
AU - Chernoff, Barry
AU - Omer, Arina
AU - Colaric, Zane
AU - Chan, Eva K. F.
AU - Minoche, Andre E.
AU - Smith, Timothy P. L.
AU - Gilbert, M. Thomas P.
AU - Bogdanovic, Ozren
AU - Zammit, Robert A.
AU - Thomas, Torsten
AU - Aiden, Erez L.
AU - Ballard, J. William O.
N1 - Publisher Copyright: © 2022 The Authors.
PY - 2022
Y1 - 2022
N2 - Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo.
AB - Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo.
U2 - 10.1126/sciadv.abm5944
DO - 10.1126/sciadv.abm5944
M3 - Journal article
C2 - 35452284
AN - SCOPUS:85128884921
VL - 8
JO - Science advances
JF - Science advances
SN - 2375-2548
IS - 16
M1 - eabm5944
ER -
ID: 307745688