Genomic insights into the conservation status of the world's last remaining Sumatran rhinoceros populations
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Genomic insights into the conservation status of the world's last remaining Sumatran rhinoceros populations. / von Seth, Johanna; Dussex, Nicolas; Diez-del-Molino, David; van der Valk, Tom; Kutschera, Verena E.; Kierczak, Marcin; Steiner, Cynthia C.; Liu, Shanlin; Gilbert, M. Thomas P.; Sinding, Mikkel-Holger S.; Prost, Stefan; Guschanski, Katerina; Nathan, Senthilvel K. S. S.; Brace, Selina; Chan, Yvonne L.; Wheat, Christopher W.; Skoglund, Pontus; Ryder, Oliver A.; Goossens, Benoit; Gotherstrom, Anders; Dalen, Love.
In: Nature Communications, Vol. 12, No. 1, 2393, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genomic insights into the conservation status of the world's last remaining Sumatran rhinoceros populations
AU - von Seth, Johanna
AU - Dussex, Nicolas
AU - Diez-del-Molino, David
AU - van der Valk, Tom
AU - Kutschera, Verena E.
AU - Kierczak, Marcin
AU - Steiner, Cynthia C.
AU - Liu, Shanlin
AU - Gilbert, M. Thomas P.
AU - Sinding, Mikkel-Holger S.
AU - Prost, Stefan
AU - Guschanski, Katerina
AU - Nathan, Senthilvel K. S. S.
AU - Brace, Selina
AU - Chan, Yvonne L.
AU - Wheat, Christopher W.
AU - Skoglund, Pontus
AU - Ryder, Oliver A.
AU - Goossens, Benoit
AU - Gotherstrom, Anders
AU - Dalen, Love
PY - 2021
Y1 - 2021
N2 - Highly endangered species like the Sumatran rhinoceros are at risk from inbreeding. Five historical and 16 modern genomes from across the species range show mutational load, but little evidence for local adaptation, suggesting that future inbreeding depression could be mitigated by assisted gene flow among populations.Small populations are often exposed to high inbreeding and mutational load that can increase the risk of extinction. The Sumatran rhinoceros was widespread in Southeast Asia, but is now restricted to small and isolated populations on Sumatra and Borneo, and most likely extinct on the Malay Peninsula. Here, we analyse 5 historical and 16 modern genomes from these populations to investigate the genomic consequences of the recent decline, such as increased inbreeding and mutational load. We find that the Malay Peninsula population experienced increased inbreeding shortly before extirpation, which possibly was accompanied by purging. The populations on Sumatra and Borneo instead show low inbreeding, but high mutational load. The currently small population sizes may thus in the near future lead to inbreeding depression. Moreover, we find little evidence for differences in local adaptation among populations, suggesting that future inbreeding depression could potentially be mitigated by assisted gene flow among populations.
AB - Highly endangered species like the Sumatran rhinoceros are at risk from inbreeding. Five historical and 16 modern genomes from across the species range show mutational load, but little evidence for local adaptation, suggesting that future inbreeding depression could be mitigated by assisted gene flow among populations.Small populations are often exposed to high inbreeding and mutational load that can increase the risk of extinction. The Sumatran rhinoceros was widespread in Southeast Asia, but is now restricted to small and isolated populations on Sumatra and Borneo, and most likely extinct on the Malay Peninsula. Here, we analyse 5 historical and 16 modern genomes from these populations to investigate the genomic consequences of the recent decline, such as increased inbreeding and mutational load. We find that the Malay Peninsula population experienced increased inbreeding shortly before extirpation, which possibly was accompanied by purging. The populations on Sumatra and Borneo instead show low inbreeding, but high mutational load. The currently small population sizes may thus in the near future lead to inbreeding depression. Moreover, we find little evidence for differences in local adaptation among populations, suggesting that future inbreeding depression could potentially be mitigated by assisted gene flow among populations.
KW - GENETIC RESCUE
KW - INBREEDING DEPRESSION
KW - HOMOZYGOSITY
KW - RESTORATION
KW - UNITS
KW - RUNS
KW - ADAPTATION
KW - MANAGEMENT
KW - DIVERSITY
KW - INFERENCE
U2 - 10.1038/s41467-021-22386-8
DO - 10.1038/s41467-021-22386-8
M3 - Journal article
C2 - 33896938
VL - 12
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 2393
ER -
ID: 272373700